SERMORELIN ACETATE

Beschrijving

Sermorelin Acetate is a synthetic 29-amino acid peptide (GRF 1-29) that mimics the active portion of endogenous growth hormone-releasing hormone (GHRH), binding to GHRH receptors on pituitary somatotroph cells to stimulate pulsatile secretion of natural human growth hormone (hGH). Unlike direct hGH administration, Sermorelin Acetate preserves the body’s natural feedback mechanisms, promoting more physiological GH release patterns with lower risk of supraphysiological IGF-1 levels or pituitary suppression. Originally FDA-approved in the 1990s for diagnostic evaluation of GH deficiency and treatment of idiopathic GH deficiency in children, Sermorelin is no longer commercially marketed under that approval as of 2026, but it remains widely available through compounding pharmacies for off-label adult use in hormone optimization, age-related GH decline, and wellness protocols. In adults, Sermorelin Acetate is researched and used to address symptoms of low GH/IGF-1, with reported benefits including increased lean muscle mass and strength, accelerated fat loss (especially abdominal/visceral fat), faster recovery from exercise or injury, improved sleep quality and deeper REM stages, enhanced skin thickness/elasticity and wound healing, increased bone mineral density, boosted energy levels and exercise capacity, better mood/cognitive function, and support for metabolic health (improved insulin sensitivity and lipid profiles in some studies) when combined with proper nutrition, resistance training, and lifestyle optimization. Typical adult protocols involve subcutaneous injection (usually 100–300 mcg once daily at bedtime to align with natural nocturnal GH pulses), with doses titrated based on age, gender, body composition goals, and regular monitoring of IGF-1, hGH, glucose, and other markers. Sermorelin Acetate is generally well-tolerated with common side effects limited to mild injection-site reactions, transient flushing, headaches, dizziness, or occasional water retention/joint discomfort (often resolving with dose adjustment); serious risks are rare but include potential insulin resistance or exacerbation of preexisting conditions. It requires a prescription and medical supervision with baseline and periodic bloodwork (IGF-1, fasting glucose, thyroid panel, CBC) to ensure safety, efficacy, and appropriate use. Sermorelin Acetate is not FDA-approved for adult growth hormone insufficiency, anti-aging, performance enhancement, or general wellness as of 2026—use is off-label/compounded and should only occur under qualified medical guidance with thorough risk-benefit assessment. Always consult a healthcare provider experienced in peptide or hormone therapy for personalized dosing, monitoring, and integration into a comprehensive health plan. Sermorelin Acetate offers a targeted, upstream approach to supporting natural GH production and vitality when benefits outweigh risks.