MGF

Beskrivelse

MGF (Mechano Growth Factor), also known as IGF-1Ec, is a naturally occurring splice variant of insulin-like growth factor-1 (IGF-1) produced in response to mechanical overload or muscle damage. This C-terminal peptide fragment (often studied as a 24-amino acid sequence or its E-domain) is expressed locally in skeletal muscle following exercise, injury, or stretch, acting as a key mediator of tissue repair and adaptation. Unlike full-length IGF-1, MGF is rapidly upregulated in a pulse-like manner post-damage, stimulating satellite cell (muscle stem cell) proliferation and fusion, delaying senescence in progenitor cells, enhancing myoblast migration, and promoting protein synthesis for muscle regeneration without broadly elevating systemic IGF-1 levels. Preclinical studies (in rodents, porcine models, and human cell cultures) demonstrate MGF’s potential to accelerate healing of muscle tears, tendon injuries, bone defects, and cartilage damage, improve osteoblast proliferation for bone repair, reduce inflammation, modulate macrophage resolution in injured muscle, and support overall tissue remodeling. In fitness, bodybuilding, and regenerative medicine communities, synthetic MGF (often the E-domain or PEGylated forms like PEG-MGF for extended stability) is researched via subcutaneous or intramuscular injection near the target site (typical anecdotal/research doses 200-500 mcg post-workout or injury, 2-3 times weekly) to enhance localized recovery, reduce downtime from training, support hypertrophy, and aid rehabilitation from strains or overuse. PEG-MGF variants aim to prolong activity for better systemic effects. While promising in animal and in vitro research for muscle progenitor activation, wound healing, and anti-aging muscle effects, MGF is not FDA-approved for any therapeutic, performance enhancement, or medical use as of 2026—it remains an investigational research peptide with limited human clinical data beyond early observations. Evidence relies primarily on preclinical models, small-scale studies, and widespread anecdotal reports rather than large randomized controlled trials confirming long-term efficacy or safety in humans. Reported side effects from user experiences are generally mild (injection-site irritation, temporary fatigue, or localized swelling), but unknowns persist regarding immunogenicity, potential off-target growth effects, or long-term risks like abnormal cell proliferation. It is prohibited by WADA for athletes and should never be used without supervision from a qualified healthcare provider experienced in peptides, as self-administration carries risks of contamination from unregulated sources, improper dosing, adverse reactions, or legal issues. Prioritize evidence-based recovery strategies—proper training, nutrition, rest, and approved therapies—for muscle repair and performance goals. Consult a professional to assess suitability, and stay informed on emerging research or regulatory developments. MGF is not a substitute for proven medical treatments or rehabilitation protocols.